Betablocker bei Sepsis STRESS-L-Studie: Das Ende der Betablocker in der Sepsis? Landiolol and organ failure in patients with septic shock: The stress-l randomized clinical trial. Whitehouse T, Hossain A, Perkins GD, Gordon AC, Bion J, Young D,...
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Betablocker bei Sepsis STRESS-L-Studie: Das Ende der Betablocker in der Sepsis? Landiolol and organ failure in patients with septic shock: The stress-l randomized clinical trial. Whitehouse T, Hossain A, Perkins GD, Gordon AC, Bion J, Young D, McAuley D, Singer M, et al. JAMA 2023; 330:1641-1652 IMPORTANCE: Patients with septic shock undergo adrenergic RESULTS: The trial was stopped prematurely on the advice of the stress, which affects cardiac, immune, inflammatory, and metabolic independent data monitoring committee because it was unlikely to pathways. ß-Blockade may attenuate the adverse effects of catecho- demonstrate benefit and because of possible harm. Of a planned 340 lamine exposure and has been associated with reduced mortality. participants, 126 (37%) were enrolled (mean age, 55.6 years [95% CI, OBJECTIVES: To assess the efficacy and safety of landiolol in 52.7 to 58.5 years]; 58.7% male). The mean (SD) SOFA score in the patients with tachycardia and established sept
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