Hiv Specific Neutralizing Antibodies By Target

HIV-Specific Neutralizing Antibodies by Target This graphic depicts HIV’s spike protein—or envelope (Env) protein—and broadly neutralizing antibodies that target key regions that play a role in infection of human (host) cells. Antibodies listed in color are... More

HIV-Specific Neutralizing Antibodies by Target This graphic depicts HIV’s spike protein—or envelope (Env) protein—and broadly neutralizing antibodies that target key regions that play a role in infection of human (host) cells. Antibodies listed in color are those that have been through any phase of clinical testing. gp41 MPER Fusion peptide Inserts into and disrupts host cell membrane, Helps disrupt viral membrane during fusion allowing HIV to release genetic material of HIV with host cell. into the cell. gp120-41 interface MPER: Membrane-proximal external region Where gp120 and gp41 meet; involved in 2F5 4E10 10E8VLS 10E8.4 ACS202 VRC34.01 structural changes to the Env protein during entry into the host cell. 35022 LN02 SANC 195 V3-glycan 8ANC195 PGT151 Involved in the initial interaction and resulting fusion between the Env protein and a coreceptor in the host cell membrane. gp120 Silent face 10-1074 DH270 PGT121.414.LS A region of the Env protein that 10-1074LS PGT121 PGT128 is heav Less