Report on influenza – Report prepared by 1. Dr. Sajid Mahmood, MD (EU), Accident & Emergency Department, NHS Royal infirmary Liverpool United Kingdom. 2. Dr. Adnan Akram, MD (EU), Department of Infectious Diseases. University Hospital Riga Latvia. 3. Dr.

pg-1 Report on influenza – ethiology, epidermiology, pathogenesis, treatment Ethiology - caused by influenza virus – orthomixoviridae family – 3 types A,B,C – single stranded RNA . 8 pieces. Influenza A has 2 main surface antigens – Haemaglutin (H) &... More

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Report on influenza – ethiology, epidermiology, pathogenesis, treatment
Ethiology - caused by influenza virus – orthomixoviridae family – 3 types A,B,C – single stranded RNA .
8
pieces.

Influenza A has 2 main surface antigens – Haemaglutin (H) & Neuraminidase (NA).

(H)- responcible for cell attachment to host cell and agglutination of RBC further divided into H1,H2,H3.

(NA) – Prevent self aggregation and promoting dispersion during budding of new virions from the infected cell.

Responsible for receptor destruction.
Divided into N1,N2.

Epidermiology – transmitted by humans, thru respiratory droplets.
IP – 6hrs- 2day
Antigenic shift – occurs when major change in antigenic type H2N2—H3N3 occurs due to new RNA segments
and are the reason for major pandemics.
Antigenic drift – relatively frequent minor changes in antigenic type H /
N this is due to small mutations in RNA segments.

Pathogenesis – Transmission via droplet inhalation – virus binds to respiratory epithelium – rep Less