OBJECTIVES: Heartburn and acid refl ux are common medical disorders in pregnancy and can result in serious discomfort and complications. Furthermore, some pregnant women also experience more severe gastrointestinal conditions, such as Helicobacter pylori...
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OBJECTIVES: Heartburn and acid refl ux are common medical disorders in pregnancy and can result in serious discomfort and complications. Furthermore, some pregnant women also experience more severe gastrointestinal conditions, such as Helicobacter pylori infections, peptic ulcers, and Zollinger – Ellison syndrome. To allow the use of proton pump inhibitors (PPIs) in pregnancy, the fetal safety of this drug class must be established. The aim of this study is to determine the fetal safety of PPIs during early pregnancy through systematic literature review.
METHODS: All original research assessing the safety of PPIs in pregnancy was sought from inception to July 2008. Two independent reviewers identifi ed articles, compared results, and settled differences through consensus. The Downs – Black scale was used to assess quality. Data assessed included congenital malformations, spontaneous abortions, and preterm delivery. A random effects metaanalysis combined the results from included studie
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